This drug may decrease your body's ability to fight infection. * Sex and gender exist on spectrums. Some rare side effects of Prolia can be serious and need medical attention. But weight gain may be a symptom of a side effect called peripheral edema. These types of medications come in forms that are taken by mouth and forms that are given by injection. Last updated on Feb 8, 2023. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. Talk with your doctor about the risks of using this drug during pregnancy. So, if you want to stop taking Prolia, talk with your doctor. 2023 Healthline Media LLC. As you age, your BMD is reduced, and this may increase your risk for osteoporosis. See additional information. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. For Prolia, talk to your pediatrician regarding the use of this medicine in children. WebDrug interactions are reported among people who take Prolia and Calcium. But its believed that these side effects are rare. For more information, you can refer to the drugs prescribing information. Serious side effects of Prolia that have been reported include: For most people, Prolias side effects are mild and go away after a few days to a few weeks. Prolia works by blocking osteoclasts (certain bone cells) from breaking down bone tissue in your body. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. You should always consult your doctor or another healthcare professional before taking any medication. You should not take Prolia if youve ever had an allergic reaction to Prolia or any of its ingredients. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. Lifestyle changes that can help improve cholesterol levels include exercising regularly and eating a healthy diet. Your low blood calcium must be treated before you receive Prolia. Some research has shown that alcohol consumption may increase your risk of osteoporosis, a bone fracture or impaired healing after a fracture. What should I know about Prolia vs. Xgeva? If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. Treating any mouth or dental problems early is the best way to help prevent serious dental complications. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. Your doctor will explain how Prolia will be given to you. These factors include what your insurance plan covers. Some items may interact with your medicine. Pay special attention to your dental hygiene. Prolia solution is available in one strength: 60 milligrams per milliliter (mg/mL). (With off-label use, a drug is used to treat conditions other than those its been approved to treat.) But some females* who received Prolia for osteoporosis after menopause had to stop Prolia treatment due to back pain. Prolia is usually given once every 6 months. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. Keep in mind that side effects of a drug can depend on: Additionally, you may experience different side effects from those listed below based on the condition youre treating with Prolia. Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. Do not take this medicine with any of the following medications: This medicine may also interact with the following medications: This list may not describe all possible interactions. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments have happened in people who take Prolia. The risk is real, but rare. With bone loss, your body loses old bone tissue faster than it makes new bone tissue. Women going through menopause have a higher risk of developing osteoporosis. Drug class: miscellaneous bone resorption inhibitors. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. (Hint: it's not just. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. This could include having: Before taking Prolia, share your dental history with your doctor. Xgeva is another brand of denosumab used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. Do not stop using this medicine without first talking to your doctor. All rights reserved. Now i am worried that i've been taking K2 which also takes calcium from the blood to the bones. Tingling wasnt specifically reported as a side effect of Prolia in clinical trials. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. What should I know about Prolia vs. Evenity? And be sure to let your doctor know about all the medications youre currently taking. Adults over age 50 should not exceed 2,000 mg total per day. Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. To learn more about this, see the How is Prolia administered? section below. Drug interactions are reported among people who take Prolia and Calcium. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. This may include acetaminophen (Tylenol), naproxen (Aleve), or ibuprofen (Advil, Motrin). Prolia is a RANKL inhibitor. Let your doctor know if you have questions about which drug is recommended for you. (Biosimilars are like generic drugs. Brush and floss your teeth regularly. Its possible that some of Prolias side effects may be long term, but theyre rare. Is the ketogenic diet right for autoimmune conditions? Hair loss with Prolia was reported after the drugs initial studies were done and it was approved for use. Other drugs may interact with denosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Web You will receive Prolia 1 time every 6 months. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. Kidney problems. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. This medication guide provides information about the Prolia brand of denosumab. (A low blood calcium level is a possible side effect of Prolia.). Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. WebMost people can get adequate calcium through their diet if they make an effort. Women But if youre planning to have surgery, you may need to take a break What's the difference between Prolia and Reclast? You should also take calcium and vitamin D supplements while being Learn about compression fractures, preventive medications, and, Preventing osteoporosis can help you prevent fractures and maintain strength as you age. For a basic overview of Prolia, including details about its uses, see this article. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. They include bone pain, back pain, and a higher risk of certain infections. If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. Call your doctor for medical advice about side effects. Its important to discuss all your concerns with your doctor. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or; if you are pregnant. These articles might help: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. No, weight gain wasnt reported as a side effect of Prolia in clinical trials. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. for breast cancer that has not spread to other parts of the body. Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. With osteopenia, your bone mineral density (BMD) is lower than usual. generic drugs) are not considered. may occur. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Some people who take Prolia develop severe bone, joint, or muscle pain. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Our phase IV clinical studies alone cannot establish cause-effect relationship. Continue reading. Prolia contains the same medicine as XGEVA (denosumab). Every 6 months youll get another dose of Prolia. If you have low blood calcium, it may get worse during treatment. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. You may report side effects to FDA at 1-800-FDA-1088. (Biosimilars are like generic drugs. Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. It is often used in osteoporosis. Because these reports happened after the studies, it isnt known for sure whether Prolia caused hair loss, or if it was due to another reason. You should always consult your doctor or another healthcare professional before taking any medication. If you have osteoporosis or bone loss, your doctor may discuss Prolia as a treatment option. Prolia isnt approved to treat osteopenia or arthritis. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. Medication Guide. Learn more about your health after menopause. If youre concerned about hair loss with Prolia, talk with your doctor. Its not known if Prolia is safe or effective for use in children. So, your bones become weak and brittle. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. These supplements help to prevent a low calcium level while youre taking Prolia. If you have bothersome or severe side effects or other problems while taking Prolia and need to stop the medication, your doctor will monitor your bone mineral density. Q: Does AlgaePlus Increase Bone Mass? But this isnt the case with Prolia. Prolia is used in adults to treat osteoporosis or bone loss in people who: who cannot use another osteoporosis medicine or these medicines did not work well. Constipation was also reported as a side effect in females using Prolia for osteoporosis. The lists below describe some of the more common side effects that Prolia may cause. You may wonder how Prolia compares with the alternative drug Reclast. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. Over time, Prolia can reduce bone loss and make your bones stronger. Talk with your doctor if youd like to know about taking generic denosumab. Factors to consider include those in the list below. Denosumab is contraindicated in women with hypocalcaemia. What should I know about Prolia vs. Zometa? What should I know about Prolia vs. Fosamax? In rare cases, your doctor may have you self-inject Prolia at home. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, 11 ways to increase bone density naturally, 14 of the best calcium supplements in 2023. Dosage of drugs is not considered in the study. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. You should talk with your doctor if you develop any mild side effects that concern you. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). Prescribing Information and A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. A biologic drug is made from parts of living organisms. Do not reuse a needle or syringe. Musculoskeletal pain from Prolia is mild or manageable for most people. RA is an autoimmune condition in which your immune system attacks your joints. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. Osteoporosis medications and medication-related osteonecrosis of the jaw. Your doctor can provide more information to you about the benefits and risks of using Prolia for your condition. But certain choices and habits accelerate the process. Throw away a prefilled syringe after one use, even if there is still medicine left inside. Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. Bone pain from Prolia may be most noticeable in your arms and legs. But nausea may be a symptom of side effects such as vertigo or constipation. This helps treat osteoporosis by improving bone mass and strengthening your bones. Your risk for some health conditions increases when you are postmenopausal. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. But its not clear whether this side effect occurred in clinical studies. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. For more information about how these medications compare with each other, ask your doctor. To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. No, Prolia isnt a bisphosphonate. Heres a short list of some of the mild side effects that Prolia can cause. What Health Changes Should You Expect Postmenopause? They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. The most common side effects of Prolia in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. Prolias manufacturer also provides some self-injection instructions, as well as a video to show you how to inject Prolia. 2,4. It can have some side effects, but these may depend on who uses it. Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. Follow your doctor's instructions. This makes your bones weak and increases your risk for bone fractures or breaks. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). If you have a low calcium level, you should not take Prolia. You can often relieve mild pain in your back or bones with an over-the-counter (OTC) pain medication. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). They also include any added costs of the drug being given by a healthcare professional. Its used to lower the risk of bone fractures in people with certain other conditions. They can help answer any questions you have about side effects from taking the drug. Coral calcium is also used in maxillofacial surgery and bone grafting. It is important not to miss your dose. If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. They can tell you more about benefits and risks of Prolia and Forteo. Talk with your doctor about which other treatments are better choices for you. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. You can use the study as a second opinion to make health care decisions. But if you think youre having a medical emergency, call 911 or your local emergency number. An allergic reaction is possible after using Prolia. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. Are there lifestyle changes that can help my osteoporosis. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Call your doctor or health care professional if you are unable to keep an appointment. Doing so will help to prevent dental problems. 8,432 people who take Prolia and Calcium together, and have interactions are studied. Prolia and Evenity are both biologic medications, but Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. You can learn more about how we ensure our content is accurate and current by reading our. A healthcare provider will give you this injection. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia. Ask your plan if they cover the drug, and what the cost will be for you. After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. You might wonder how Prolia and the drug Xgeva compare. Youll likely have questions about your condition and treatment choices. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Patients should not stop Prolia treatment without first consulting your These are not all the possible side effects of Prolia. Will my fracture risk come back if I stop Prolia treatment? If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. To learn how Prolia and Tymlos are alike and different, see this comparison. Cleveland Clinic is a non-profit academic medical center. Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. In addition, you should use effective birth control while youre taking Prolia. MNT is the registered trade mark of Healthline Media. Youll get Prolia injections from a healthcare professional once every 6 months. Tell your doctor about all other medicines you use. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. If youd like a detailed comparison of Prolia versus Boniva, view this article. Talk to your health care professional or pharmacist for more information. Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. Specifically, Prolia is a monoclonal antibody (a lab-made protein). Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. It is important to check supplement labels to ensure that the product meets United States Pharmacopeia (USP) standards. Nonmetastatic means the cancer hasnt spread to other areas of the body. Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. This may help to protect healthy cells from damage. Serious side effects from Prolia can occur, but they arent common. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. Youll receive Prolia doses from a healthcare professional. There arent any reported interactions between Prolia and alcohol. This means your bones may be weaker than usual. Learn how to increase or maintain bone density here. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. Prolia can also cause low calcium levels. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. Osteoporosis is a condition that causes your bones to become thin and weak. WebIn many individuals, calcium supplements are better absorbed when taken with food. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. For instance, if you have a health condition that causes excess calcium in Theyll discuss with you other treatments to help prevent bone loss. * Sex and gender exist on spectrums. 1 shot every 6 months could mean fewer doses. Youll receive Prolia doses from a healthcare professional. Keep out of the reach of children and pets. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Different individuals may respond to medication in different ways. If youre concerned about weight gain with Prolia, talk with your doctor. Both are prescription medicines. This medicine is only given in a clinic, doctor's office, or other health care setting and will not be stored at home. As mentioned above, Prolia contains the active drug denosumab. What is the most important information I should know about Prolia? The use of the eHealthMe site and its content is at your own risk. * Approximation only. Various types of osteoporosis medications are available. Learn more about some of the side effects Prolia may cause. American Dental Association (ADA) recommendations say that tooth extractions are allowable if needed during Prolia treatment, if both you and your dentist agree. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days.
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